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The FDA is said to have recently instituted a crack down on weight loss supplements as a result of very bad side effects and even death linked to some dietary supplements such as ephedra. The ban on ephedra items resulted to the introduction of so-called ephedra free weight loss supplements, these too have been shown to yield their own fair share of problems and they too could be most likely going to the same fate as ephedra.

These ephedra free supplements have been shown to trigger an increase in heart rate and a couple other side effects on healthy people reported by a health expert who was in the study.

The examination conducted by the University of California at Berkeley was the first one to look into the health effects of reformulated weight loss supplements. Among the things analyzed for included blood pressure and pulse rate of volunteers who were given reformulated weight loss supplements created from extracts of bitter orange.

Since the ban slapped on ephedra by FDA, an increasing number of weight loss product manufactures have turned to extracts of bitter orange. The USB research involved 20 healthy volunteers, who received single doses of a weight loss supplement or a placebo.

The diet supplements screened in the study were Xenadrine EFX and Advantra Z, each of which contains bitter orange extracts. The administered drug was shown to effect an increase in heart pulse rate of up to 16 beats in one minute. The Thermogenic Xenadrine EFX for example was shown to rev up heart rate by 13 per cent, a thing that makes it almost similar in performance to ephedra.

Bitter orange extracts contain synephrine, a component present in over 90% of citrus fruits but found in higher concentrations in fruits such as Sour orange, Zhi shi and bitter orange and which happens to be popularly used as a remedy in the management of respiratory tract congestion and high blood pressure. Xenadrine EFX includes a stimulant in the ingredient, usually caffeine. The quantity of caffeine is Xenadrine is estimated to be the equivalent of 3 coffee cups. This is the component responsible for the surge in blood pressure and patients using this product are cautioned against over dosage.

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